Its prolonged effect may help alleviate medication noncompliance, one of the leading causes of failure to lower LDL-C levels. In contrast to statins, it requires infrequent dosing (twice per year) and provides effective and sustained LDL-C reduction in conjunction with statins. Inclisiran is an injectable, chemically synthesized small interfering RNA that targets the PCSK9 protein. In 2019, the FDA reviewed the application for inclisiran in treating primary hyperlipidemia (including hereditary hypercholesterolemia) in adults who have elevated LDL-C while on a maximally tolerated dose of statin therapy. High levels of blood cholesterol, particularly low-density lipoproteins (LDL-C), are a significant contributor to cardiovascular disease. In 2020, this technology received FDA approval based on phase 3 trials that showed a substantially increased accuracy for detecting prostate cancer metastases compared to conventional imaging with bone and CT scans.ģ. This approach can be used in conjunction with CT or MRI scans to visualize where prostate cancer cells reside. PSMA PET uses a radioactive tracer to locate and attach to PSMA proteins, making them visible by PET imaging. Prostate-specific membrane antigen (PSMA), found in high levels on the surface of prostate cancer cells, is a potential biomarker of the disease. Early detection and successful imaging are critical for tumor localization, staging the disease and detecting recurrences. Each year, more than 200,000 Americans are diagnosed with prostate cancer - the most commonly diagnosed cancer among U.S. This landscape-changing technology has the potential to quickly and efficiently eliminate some of healthcare’s most challenging diseases.Ģ. Because of previous research that laid the groundwork for this technology, an effective COVID-19 vaccine was developed, produced, approved and deployed in less than a year. Furthermore, the COVID-19 pandemic demonstrated that the world needed rapid development of a vaccine that was easily deployable around the globe. The technology is cost-effective and relatively simple to manufacture. Advancements in the generation, purification and cellular delivery of RNA have enabled the development of RNA therapies across a broad array of applications, such as cancer and Zika virus.
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